ObjectiveCyclin-dependent kinase 1 (CDK1)/cyclin B1 phosphorylates many of the same substrates as mTORC1 (a key regulator of glucose metabolism), including the eukaryotic initiation factor 4E-binding protein 1 (4E-BP1).Only mitotic CDK1 phosphorylates 4E-BP1 at residue S82 in mice (S83 in humans), in addition to the Dab Rig common 4E-BP1 phospho-ac
Umbilical cord mesenchymal stem cells (UCMSCs) have the best ability to travel to the tumor site and they serve as a tool to fight cancer.This study showed that secretome from Nail Tips UCMSCs (UCMSCs-Sec) could inhibit the growth of prostate cancer (PC-3) and cervical cancer (HeLa) cells, and induce apoptosis in the cells.The UCMSCs-Sec treatment
Abstract Background In biological systems, metabolomics can not only contribute to the discovery of metabolic signatures for disease diagnosis, but is very helpful to illustrate the underlying molecular disease-causing mechanism.Therefore, identification of disease-related metabolites is of great significance for comprehensively understanding Massa
Malaria represents a major health problem in Yemen, and it appears that the efforts devoted to its control and elimination only tackle the tip of malaria iceberg.There is an evident gap between research activities and control efforts reflected by the fact that efforts and funding allocation are mainly directed to control activities.Research on basi
Introduction: The extraction of premolars as a practical form of orthodontic therapy has been accepted for many years, but there remains a controversy regarding the effect of premolar extraction to improve esthetics as well as dentoskeletal relationship.The esthetic impact of the soft-tissue profile might play a major role in deciding on premolar e